[HTML][HTML] The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis
M Kono, Y Mi, Y Liu, T Sasaki, ML Allende… - Journal of Biological …, 2004 - ASBMB
Sphingosine-1-phosphate (S1P) elicits diverse cellular responses through a family of G-
protein-coupled receptors. We have shown previously that genetic disruption of the S1P 1
receptor, the most widely expressed of the family, results in embryonic lethality because of
its key role within endothelial cells in regulating the coverage of blood vessels by vascular
smooth muscle cells. To understand the physiologic functions of the two other widely
expressed S1P receptors, we generated S1P 2 and S1P 3 null mice. Neither the S1P 2 null …
protein-coupled receptors. We have shown previously that genetic disruption of the S1P 1
receptor, the most widely expressed of the family, results in embryonic lethality because of
its key role within endothelial cells in regulating the coverage of blood vessels by vascular
smooth muscle cells. To understand the physiologic functions of the two other widely
expressed S1P receptors, we generated S1P 2 and S1P 3 null mice. Neither the S1P 2 null …