[HTML][HTML] Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression
BP Portier, G Taglialatela - Journal of Biological Chemistry, 2006 - ASBMB
Bcl-2 is the best characterized member of a large family of proteins that regulate apoptosis.
Although it is established that Bcl-2 localized at the mitochondria functions as an anti-
apoptotic protein, the function of Bcl-2 at the nucleus remains unclear. Recently we showed
that nuclear compartment-associated Bcl-2 inhibits transcription factor activation. Based on
this observation, we hypothesized that presence of Bcl-2 at the nucleus may induce rather
than protect cells from apoptosis. Here we investigated the putative apoptotic role of nuclear …
Although it is established that Bcl-2 localized at the mitochondria functions as an anti-
apoptotic protein, the function of Bcl-2 at the nucleus remains unclear. Recently we showed
that nuclear compartment-associated Bcl-2 inhibits transcription factor activation. Based on
this observation, we hypothesized that presence of Bcl-2 at the nucleus may induce rather
than protect cells from apoptosis. Here we investigated the putative apoptotic role of nuclear …