Importance Hidradenitis suppurativa is a chronic, inflammatory skin disease in which genetic
factors are considered to play a role, with up to 38% of patients reporting a family history.
Variations in the γ-secretase genes are found mainly in familial cases with an autosomal
dominant pattern of inheritance. These variations are rare in the general population with
hidradenitis suppurativa, even in patients who report a family history of the disease.
Objective To assess the heritability of hidradenitis suppurativa in a nationwide Dutch twin …