Aggregation of the microtubule associated protein Tau is associated with several
neurodegenerative disorders, including Alzheimer disease and frontotemporal dementia. In
Alzheimer disease, Tau pathology spreads progressively throughout the brain, possibly
along existing neural networks. However, it is still unclear how the propagation of Tau
misfolding occurs. Intriguingly, in animal models, vaccine-based therapies have reduced
Tau and synuclein pathology by uncertain mechanisms, given that these proteins are …