Diverse solid tumors expressing a restricted epitope of L1-CAM can be targeted by chimeric antigen receptor redirected T lymphocytes
H Hong, M Stastny, C Brown, WC Chang… - Journal of …, 2014 - journals.lww.com
Abstract Adhesion molecule L1-CAM (CD171) was originally reported to be overexpressed
on neuroblastoma and to play an important role during tumor progression. More recently, it
has been shown to be overexpressed on many other solid tumors such as melanoma and
carcinomas of the cervix, ovary, bladder, and others. Thus, there has been a growing interest
in using this cell-surface molecule as a target for both antibody-based and cellular-based
therapy—our group has previously examined the clinical utility of chimeric antigen receptor …
on neuroblastoma and to play an important role during tumor progression. More recently, it
has been shown to be overexpressed on many other solid tumors such as melanoma and
carcinomas of the cervix, ovary, bladder, and others. Thus, there has been a growing interest
in using this cell-surface molecule as a target for both antibody-based and cellular-based
therapy—our group has previously examined the clinical utility of chimeric antigen receptor …
