[HTML][HTML] VEGF signaling on hematopoietic precursors restricts B-lymphoid commitment in vitro and in vivo
R Fragoso, C Igreja, N Clode, A Henriques… - Experimental …, 2008 - Elsevier
Vascular endothelial growth factor (VEGF) signals on vascular and hematopoietic cells via
its receptors, VEGFR-2 (KDR) and VEGFR-1 (FLT-1). Elevated levels of VEGF, such as
during tumor growth or inflammation, have been suggested to suppress hematopoiesis;
most studies refer to KDR as the main receptor involved in this inhibitory effect. In the
present study, having detected expression of FLT-1 in B-lymphoid precursors, we exploited
the possibility that VEGF signaling via FLT-1 might affect early B-cell commitment. Using a …
its receptors, VEGFR-2 (KDR) and VEGFR-1 (FLT-1). Elevated levels of VEGF, such as
during tumor growth or inflammation, have been suggested to suppress hematopoiesis;
most studies refer to KDR as the main receptor involved in this inhibitory effect. In the
present study, having detected expression of FLT-1 in B-lymphoid precursors, we exploited
the possibility that VEGF signaling via FLT-1 might affect early B-cell commitment. Using a …
