[HTML][HTML] Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused
GT ZeRuth, XP Yang, AM Jetten - Journal of Biological Chemistry, 2011 - ASBMB
Glis3 is a member of the Glis subfamily of Krüppel-like zinc finger transcription factors.
Recently, Glis3 has been linked to both type I and type II diabetes and shown to positively
regulate insulin gene expression. In this study, we have identified a region within the N
terminus of Glis3 that shares high levels of homology with the Cubitus interruptus (Ci)/Gli
family of proteins. We demonstrated that Glis3 interacts with Suppressor of Fused (SUFU),
which involves a VYGHF motif located within this conserved region. We further showed that …
Recently, Glis3 has been linked to both type I and type II diabetes and shown to positively
regulate insulin gene expression. In this study, we have identified a region within the N
terminus of Glis3 that shares high levels of homology with the Cubitus interruptus (Ci)/Gli
family of proteins. We demonstrated that Glis3 interacts with Suppressor of Fused (SUFU),
which involves a VYGHF motif located within this conserved region. We further showed that …