The Notch signaling pathway is a highly conserved pathway involved in cell fate
determination in embryonic development and also functions in the regulation of
physiological processes in several systems. It plays an especially important role in vascular
development and physiology by influencing angiogenesis, vessel patterning, arterial/venous
specification, and vascular smooth muscle biology. Aberrant or dysregulated Notch
signaling is the cause of or a contributing factor to many vascular disorders, including …