Patients with chronic kidney disease have an increased cardiovascular morbidity and
mortality. It has been recognized that the traditional cardiovascular risk factors could only
partially explain the increased cardiovascular morbidity and mortality in patients with chronic
kidney disease. Asymmetric dimethylarginine (ADMA) and N-monomethy l-arginine (L-
NMMA) are endogenous inhibitors of nitric oxide synthases that attenuate nitric oxide
production and enhance reactive oxidative specie generation. Increased plasma ADMA …