Circadian rest—activity rhythm disturbances in Alzheimer's disease
EJW Van Someren, EEO Hagebeuk, C Lijzenga… - Biological …, 1996 - Elsevier
Previous studies showed circadian rhythm disturbances in patients with Alzheimer's
disease. Rest-activity rhythm disturbances manifest themselves through a fragmentation of
the rhythm, a weak coupling with Zeitgebers, and high levels of activity during the night. The
aim of the present study was to investigate which factors contribute to the presence of these
disturbances. Therefore, several rest-activity rhythm, constitutional, and environmental
variables were assessed in a heterogeneous group of 34 patients with Alzheimer's disease …
disease. Rest-activity rhythm disturbances manifest themselves through a fragmentation of
the rhythm, a weak coupling with Zeitgebers, and high levels of activity during the night. The
aim of the present study was to investigate which factors contribute to the presence of these
disturbances. Therefore, several rest-activity rhythm, constitutional, and environmental
variables were assessed in a heterogeneous group of 34 patients with Alzheimer's disease …
