Mechanism of nitric oxide–mediated intestinal barrier failure: insight into the pathogenesis of necrotizing enterocolitis
HR Ford - Journal of pediatric surgery, 2006 - jpedsurg.org
Necrotizing enterocolitis (NEC) is the most frequent and the most lethal disease that affects
the gastrointestinal (GI) tract of the premature infant [1]. The overall mortality rate for patients
with NEC ranges from 10% to 70%[2] and approaches 100% for patients with the most
severe form of the disease, which is characterized by involvement of the entire bowel (pan-
necrosis)[3]. Although numerous risk factors including prematurity, hypoxia, formula feeding,
bacterial infection, and intestinal ischemia have been implicated in the pathogenesis of NEC …
the gastrointestinal (GI) tract of the premature infant [1]. The overall mortality rate for patients
with NEC ranges from 10% to 70%[2] and approaches 100% for patients with the most
severe form of the disease, which is characterized by involvement of the entire bowel (pan-
necrosis)[3]. Although numerous risk factors including prematurity, hypoxia, formula feeding,
bacterial infection, and intestinal ischemia have been implicated in the pathogenesis of NEC …