Glomerulosclerosis induced by deficiency of membrane-associated guanylate kinase inverted 2 in kidney podocytes
N Shirata, K Ihara, K Yamamoto-Nonaka… - Journal of the …, 2017 - journals.lww.com
Membrane-associated guanylate kinase inverted 2 (MAGI-2) is a component of the slit
diaphragm (SD) of glomerular podocytes. Here, we investigated the podocyte-specific
function of MAGI-2 using newly generated podocyte-specific MAGI-2–knockout (MAGI-2–
KO) mice. Compared with podocytes from wild-type mice, podocytes from MAGI-2–KO mice
exhibited SD disruption, morphologic abnormalities of foot processes, and podocyte
apoptosis leading to podocyte loss. These pathologic changes manifested as massive …
diaphragm (SD) of glomerular podocytes. Here, we investigated the podocyte-specific
function of MAGI-2 using newly generated podocyte-specific MAGI-2–knockout (MAGI-2–
KO) mice. Compared with podocytes from wild-type mice, podocytes from MAGI-2–KO mice
exhibited SD disruption, morphologic abnormalities of foot processes, and podocyte
apoptosis leading to podocyte loss. These pathologic changes manifested as massive …
