Marked induction of c-Maf protein during Th17 cell differentiation and its implication in memory Th cell development
K Sato, F Miyoshi, K Yokota, Y Araki, Y Asanuma… - Journal of Biological …, 2011 - ASBMB
Until recently, effector T helper (Th) cells have been classified into two subsets, Th1 and Th2
cells. Since the discovery of Th17 cells, which produce IL-17, much attention has been given
to Th17 cells, mainly because they have been implicated in the pathogenesis of various
inflammatory diseases. We have performed transcriptome analysis combined with factor
analysis and revealed that the expression level of c-Maf, which is considered to be important
for Th2 differentiation, increases significantly during the course of Th17 differentiation. The IL …
cells. Since the discovery of Th17 cells, which produce IL-17, much attention has been given
to Th17 cells, mainly because they have been implicated in the pathogenesis of various
inflammatory diseases. We have performed transcriptome analysis combined with factor
analysis and revealed that the expression level of c-Maf, which is considered to be important
for Th2 differentiation, increases significantly during the course of Th17 differentiation. The IL …