Caspase-1 and caspase-8 cleave and inactivate cellular parkin
S Kahns, M Kalai, LD Jakobsen, BFC Clark… - Journal of Biological …, 2003 - ASBMB
Lesions in the parkin gene cause early onset Parkinson's disease by a loss of dopaminergic
neurons, thus demonstrating a vital role for parkin in the survival of these neurons. Parkin is
inactivated by caspase cleavage, and the major cleavage site is after Asp 126. Caspases
responsible for parkin cleavage were identified by several experimental paradigms.
Transient coexpression of caspases and wild type parkin in HEK-293 cells identified
caspase-1,-3, and-8 as efficient inducers of parkin cleavage whereas caspase-2,-7,-9, and …
neurons, thus demonstrating a vital role for parkin in the survival of these neurons. Parkin is
inactivated by caspase cleavage, and the major cleavage site is after Asp 126. Caspases
responsible for parkin cleavage were identified by several experimental paradigms.
Transient coexpression of caspases and wild type parkin in HEK-293 cells identified
caspase-1,-3, and-8 as efficient inducers of parkin cleavage whereas caspase-2,-7,-9, and …
