DEAR EDITOR, Hidradenitis suppurativa (HS) is a chronic skin disease marked by abscesses, sinus tract formation and profound scarring. Although the inflammatory nature of HS is well described, its aetiology remains elusive. Deciphering the molecular pathogenesis of HS will facilitate development of new therapeutics for this debilitating disease. Using publicly available microarray data, this exploratory work identifies differentially regulated biological pathways in HS. Blok et al., who submitted this microarray to the National Center for Biotechnology Information (NCBI) have previously identified a proinflammatory response as the prime dysregulated pathway in HS. 1 In further analysis, the present work uncovers evidence that HS lesions have increased androgen receptor (AR) transcriptional activity, activation of stem cellassociated transcriptional pathways and upregulation of Notchassociated genetic loci.