Coated pits, coated vesicles, and receptor-mediated endocytosis
JL Goldstein, RGW Anderson, MS Brown - Nature, 1979 - nature.com
JL Goldstein, RGW Anderson, MS Brown
Nature, 1979•nature.comProteins and peptides can enter cells by receptor-mediated endocytosis, a coupled process
by which selected extracellular proteins or peptides are first bound to specific cell surface
receptors and then rapidly internalised by the cell Internalisation follows clustering of the
receptors in specialised regions of the cell surface called coated pits that invaginate to form
intracellular coated vesicles. It is now recognised that receptor-mediated endocytosis has a
fundamental role in the growth, nutrition and differentiation of animal cells.
by which selected extracellular proteins or peptides are first bound to specific cell surface
receptors and then rapidly internalised by the cell Internalisation follows clustering of the
receptors in specialised regions of the cell surface called coated pits that invaginate to form
intracellular coated vesicles. It is now recognised that receptor-mediated endocytosis has a
fundamental role in the growth, nutrition and differentiation of animal cells.
Abstract
Proteins and peptides can enter cells by receptor-mediated endocytosis, a coupled process by which selected extracellular proteins or peptides are first bound to specific cell surface receptors and then rapidly internalised by the cell Internalisation follows clustering of the receptors in specialised regions of the cell surface called coated pits that invaginate to form intracellular coated vesicles. It is now recognised that receptor-mediated endocytosis has a fundamental role in the growth, nutrition and differentiation of animal cells.
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