[HTML][HTML] Serelaxin induces Notch1 signaling and alleviates hepatocellular damage in orthotopic liver transplantation
S Kageyama, K Nakamura, B Ke, RW Busuttil… - American Journal of …, 2018 - Elsevier
Liver ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and
an obstacle to expanding donor pool in orthotopic liver transplantation (OLT). We have
reported on the crucial role of macrophage Notch1 signaling in mouse warm hepatic IRI
model. However, its clinical relevance or therapeutic potential remain unknown. Here, we
used Serelaxin (SER), to verify Notch1 induction and putative hepatoprotective function in
ischemia-reperfusion–stressed OLT. C57BL/6 mouse livers subjected to extended (18-hour) …
an obstacle to expanding donor pool in orthotopic liver transplantation (OLT). We have
reported on the crucial role of macrophage Notch1 signaling in mouse warm hepatic IRI
model. However, its clinical relevance or therapeutic potential remain unknown. Here, we
used Serelaxin (SER), to verify Notch1 induction and putative hepatoprotective function in
ischemia-reperfusion–stressed OLT. C57BL/6 mouse livers subjected to extended (18-hour) …