[HTML][HTML] Negative CD4+ TIM-3 signaling confers resistance against cold preservation damage in mouse liver transplantation
Y Liu, H Ji, Y Zhang, XD Shen, F Gao… - American Journal of …, 2015 - Elsevier
Ischemia-reperfusion injury (IRI), an innate immunity-driven local inflammation, remains the
major problem in clinical organ transplantation. T cell immunoglobulin and mucin domain
(TIM-3)–Galectin-9 (Gal-9) signaling regulates CD4+ Th1 immune responses. Here, we
explored TIM-3–Gal-9 function in a clinically relevant murine model of hepatic cold storage
and orthotopic liver transplantation (OLT). C57BL/6 livers, preserved for 20 h at 4° C in UW
solution, were transplanted to syngeneic mouse recipients. Up-regulation of TIM-3 on OLT …
major problem in clinical organ transplantation. T cell immunoglobulin and mucin domain
(TIM-3)–Galectin-9 (Gal-9) signaling regulates CD4+ Th1 immune responses. Here, we
explored TIM-3–Gal-9 function in a clinically relevant murine model of hepatic cold storage
and orthotopic liver transplantation (OLT). C57BL/6 livers, preserved for 20 h at 4° C in UW
solution, were transplanted to syngeneic mouse recipients. Up-regulation of TIM-3 on OLT …