Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor …
LH Lv, YL Wan, Y Lin, W Zhang, M Yang, GL Li… - Journal of Biological …, 2012 - ASBMB
Failure of immune surveillance related to inadequate host antitumor immune responses has
been suggested as a possible cause of the high incidence of recurrence and poor overall
survival outcome of hepatocellular carcinoma. The stress-induced heat shock proteins
(HSPs) are known to act as endogenous" danger signals" that can improve tumor
immunogenicity and induce natural killer (NK) cell responses. Exosome is a novel secretory
pathway for HSPs. In our experiments, the immune regulatory effect of the HSP-bearing …
been suggested as a possible cause of the high incidence of recurrence and poor overall
survival outcome of hepatocellular carcinoma. The stress-induced heat shock proteins
(HSPs) are known to act as endogenous" danger signals" that can improve tumor
immunogenicity and induce natural killer (NK) cell responses. Exosome is a novel secretory
pathway for HSPs. In our experiments, the immune regulatory effect of the HSP-bearing …
