Evidence for the participation of cocaine-and amphetamine-regulated transcript peptide (CART) in the fluoxetine-induced anti-hyperalgesia in neuropathic rats
MA Upadhya, MP Dandekar, DM Kokare, PS Singru… - Peptides, 2011 - Elsevier
Cocaine-and amphetamine-regulated transcript peptide (CART) has a role in chronic pain,
and also in the actions of selective serotonin reuptake inhibitors (SSRIs) employed in the
treatment of neuropathic pain. Herein, we test the hypothesis that CART may mediate the
anti-hyperalgesic effect of the SSRI, fluoxetine, in neuropathic rats. Sciatic nerve in the right
hind paw of rat was ligated to induce neuropathic pain, and the paw withdrawal latency was
evaluated using Hargreaves apparatus. Fluoxetine [5–25mg/kg, intraperitoneal (ip)] or …
and also in the actions of selective serotonin reuptake inhibitors (SSRIs) employed in the
treatment of neuropathic pain. Herein, we test the hypothesis that CART may mediate the
anti-hyperalgesic effect of the SSRI, fluoxetine, in neuropathic rats. Sciatic nerve in the right
hind paw of rat was ligated to induce neuropathic pain, and the paw withdrawal latency was
evaluated using Hargreaves apparatus. Fluoxetine [5–25mg/kg, intraperitoneal (ip)] or …