The epithelial to mesenchymal transition (EMT) is a multistep biological process whereby
epithelial cells change in plasticity by transient de-differentiation into a mesenchymal
phenotype. EMT and its reversal, mesenchymal to epithelial transition (MET), essentially
occur during embryogenetic morphogenesis and have been increasingly described in
fibrosis and cancer during the last decade. In carcinoma progression, EMT plays a crucial
role in early steps of metastasis when cells lose cell-cell contacts due to ablation of E …