STAT5B deficiency: impacts on human growth and immunity
V Hwa - Growth Hormone & IGF Research, 2016 - Elsevier
Growth hormone (GH) promotes postnatal human growth primarily by regulating insulin-like
growth factor (IGF)-I production through activation of the GH receptor (GHR)-signal
transducer and activator of transcription (STAT)-5B signaling cascade. The critical
importance of STAT5B in human IGF-I production was confirmed with the identification of the
first homozygous, autosomal recessive, STAT5B mutation in a young female patient who
phenotypically resembled patients with classical growth hormone insensitivity (GHI) …
growth factor (IGF)-I production through activation of the GH receptor (GHR)-signal
transducer and activator of transcription (STAT)-5B signaling cascade. The critical
importance of STAT5B in human IGF-I production was confirmed with the identification of the
first homozygous, autosomal recessive, STAT5B mutation in a young female patient who
phenotypically resembled patients with classical growth hormone insensitivity (GHI) …
