[HTML][HTML] Decreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient mice
ME Lowe, MH Kaplan, L Jackson-Grusby… - Journal of Biological …, 1998 - ASBMB
The pancreas secretes several different lipases. The most abundant is pancreatic
triglyceride lipase (PTL). The pancreas also synthesizes two homologues of PTL, the
pancreatic lipase-related proteins 1 and 2 (PLRP1 and PLRP2). Cytotoxic T-lymphocytes
also express PLRP2 under certain conditions. We sought to determine the role of PLRP2 in
fat absorption and in T-cell cytotoxicity by creating a PLRP2-deficient mouse. Adult PLRP2-
deficient mice had normal fat absorption. In contrast, suckling PLRP2-deficient mice had fat …
triglyceride lipase (PTL). The pancreas also synthesizes two homologues of PTL, the
pancreatic lipase-related proteins 1 and 2 (PLRP1 and PLRP2). Cytotoxic T-lymphocytes
also express PLRP2 under certain conditions. We sought to determine the role of PLRP2 in
fat absorption and in T-cell cytotoxicity by creating a PLRP2-deficient mouse. Adult PLRP2-
deficient mice had normal fat absorption. In contrast, suckling PLRP2-deficient mice had fat …