Human NACHT, LRR, and PYD domain–containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase
X Liu, T Pichulik, OO Wolz, TM Dang, A Stutz… - Journal of Allergy and …, 2017 - Elsevier
Background The Nod-like receptor NACHT, LRR, and PYD domain–containing protein 3
(NLRP3) and Bruton tyrosine kinase (BTK) are protagonists in innate and adaptive immunity,
respectively. NLRP3 senses exogenous and endogenous insults, leading to inflammasome
activation, which occurs spontaneously in patients with Muckle-Wells syndrome; BTK
mutations cause the genetic immunodeficiency X-linked agammaglobulinemia (XLA).
However, to date, few proteins that regulate NLRP3 inflammasome activity in human primary …
(NLRP3) and Bruton tyrosine kinase (BTK) are protagonists in innate and adaptive immunity,
respectively. NLRP3 senses exogenous and endogenous insults, leading to inflammasome
activation, which occurs spontaneously in patients with Muckle-Wells syndrome; BTK
mutations cause the genetic immunodeficiency X-linked agammaglobulinemia (XLA).
However, to date, few proteins that regulate NLRP3 inflammasome activity in human primary …