Cardiac and respiratory involvement in advanced stage Duchenne muscular dystrophy
P Melacini, A Vianello, C Villanova, M Fanin… - Neuromuscular …, 1996 - Elsevier
This study aimed to describe myocardial involvement, respiratory impairment and pulmonary
blood flow abnormalities in advanced-stage Duchenne muscular dystrophy (DMD). Twenty-
one wheelchair-bound patients, aged from 10 to 24 yr, underwent electrocardiographic and
echocardiographic examination, conventional spirometry, diurnal arterial blood gas
analysis, and nocturnal polysomnography (SaO2 monitoring). Diagnosis was confirmed by
neurological examination, dystrophin analysis at protein and DNA level. Patients were …
blood flow abnormalities in advanced-stage Duchenne muscular dystrophy (DMD). Twenty-
one wheelchair-bound patients, aged from 10 to 24 yr, underwent electrocardiographic and
echocardiographic examination, conventional spirometry, diurnal arterial blood gas
analysis, and nocturnal polysomnography (SaO2 monitoring). Diagnosis was confirmed by
neurological examination, dystrophin analysis at protein and DNA level. Patients were …