Fibroblast growth factor-23 and cardiovascular events in CKD
JJ Scialla, H Xie, M Rahman… - Journal of the …, 2014 - journals.lww.com
An elevated level of fibroblast growth factor-23 (FGF-23) is the earliest abnormality of
mineral metabolism in CKD. High FGF-23 levels promote left ventricular hypertrophy but not
coronary artery calcification. We used survival analysis to determine whether elevated FGF-
23 is associated with greater risk of adjudicated congestive heart failure (CHF) and
atherosclerotic events (myocardial infarction, stroke, and peripheral vascular disease) in a
prospective cohort of 3860 participants with CKD stages 2–4 (baseline estimated GFR …
mineral metabolism in CKD. High FGF-23 levels promote left ventricular hypertrophy but not
coronary artery calcification. We used survival analysis to determine whether elevated FGF-
23 is associated with greater risk of adjudicated congestive heart failure (CHF) and
atherosclerotic events (myocardial infarction, stroke, and peripheral vascular disease) in a
prospective cohort of 3860 participants with CKD stages 2–4 (baseline estimated GFR …