[HTML][HTML] Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines
J Sirén, T Imaizumi, D Sarkar, T Pietilä, DL Noah… - Microbes and …, 2006 - Elsevier
Activation of host cell antiviral responses is mediated by pattern recognition receptors.
Cytoplasmic RNA helicases, retinoic acid inducible gene-I (RIG-I) and melanoma
differentiation-associated gene 5 (mda-5) have been identified to function as receptors for
double-stranded RNA. Here we show that interferon (IFN)-α pretreatment enhances
influenza A virus-induced expression of IFN-α, IFN-β, interleukin (IL)-28 and IL-29 genes in
human dendritic cells and epithelial cell lines. Both IFN-α and IFN-β strongly enhanced RIG-I …
Cytoplasmic RNA helicases, retinoic acid inducible gene-I (RIG-I) and melanoma
differentiation-associated gene 5 (mda-5) have been identified to function as receptors for
double-stranded RNA. Here we show that interferon (IFN)-α pretreatment enhances
influenza A virus-induced expression of IFN-α, IFN-β, interleukin (IL)-28 and IL-29 genes in
human dendritic cells and epithelial cell lines. Both IFN-α and IFN-β strongly enhanced RIG-I …