Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFα-induced apoptosis
The linear ubiquitin chain assembly complex (LUBAC) regulates NF-κB activation by
modifying proteins with linear (M1-linked) ubiquitination chains. Although LUBAC also
regulates the apoptosis pathway, the precise mechanism by which LUBAC regulates
apoptosis remains not fully defined. Here, we report that LUBAC-mediated M1-linked
ubiquitination of cellular FLICE-like inhibitory protein (cFLIP), an anti-apoptotic molecule,
contributes to tumor necrosis factor (TNF) α-induced apoptosis. We found that deficiency of …
modifying proteins with linear (M1-linked) ubiquitination chains. Although LUBAC also
regulates the apoptosis pathway, the precise mechanism by which LUBAC regulates
apoptosis remains not fully defined. Here, we report that LUBAC-mediated M1-linked
ubiquitination of cellular FLICE-like inhibitory protein (cFLIP), an anti-apoptotic molecule,
contributes to tumor necrosis factor (TNF) α-induced apoptosis. We found that deficiency of …
