[HTML][HTML] TAR DNA-binding protein 43 (TDP-43) liquid–liquid phase separation is mediated by just a few aromatic residues
HR Li, WC Chiang, PC Chou, WJ Wang… - Journal of Biological …, 2018 - ASBMB
Eukaryotic cells contain distinct organelles, but not all of these compartments are enclosed
by membranes. Some intrinsically disordered proteins mediate membraneless organelle
formation through liquid–liquid phase separation (LLPS). LLPS facilitates many biological
functions such as regulating RNA stability and ribonucleoprotein assembly, and disruption of
LLPS pathways has been implicated in several diseases. Proteins exhibiting LLPS typically
have low sequence complexity and specific repeat motifs. These motifs promote multivalent …
by membranes. Some intrinsically disordered proteins mediate membraneless organelle
formation through liquid–liquid phase separation (LLPS). LLPS facilitates many biological
functions such as regulating RNA stability and ribonucleoprotein assembly, and disruption of
LLPS pathways has been implicated in several diseases. Proteins exhibiting LLPS typically
have low sequence complexity and specific repeat motifs. These motifs promote multivalent …