[HTML][HTML] TDP-43 is a developmentally regulated protein essential for early embryonic development
CF Sephton, SK Good, S Atkin, CM Dewey… - Journal of Biological …, 2010 - ASBMB
TDP-43 is a DNA/RNA-binding protein implicated in multiple steps of transcriptional and
post-transcriptional regulation of gene expression. Alteration of this multifunctional protein is
associated with a number of neurodegenerative diseases including amyotrophic lateral
sclerosis and frontotemporal lobar degeneration with ubiquitin positive inclusions. Whereas
a pathological link to neurodegenerative disorders has been established, the cellular and
physiological functions of TDP-43 remain unknown. In this study, we show that TDP-43 is a …
post-transcriptional regulation of gene expression. Alteration of this multifunctional protein is
associated with a number of neurodegenerative diseases including amyotrophic lateral
sclerosis and frontotemporal lobar degeneration with ubiquitin positive inclusions. Whereas
a pathological link to neurodegenerative disorders has been established, the cellular and
physiological functions of TDP-43 remain unknown. In this study, we show that TDP-43 is a …