Essentials• Antiangiogenic drugs are indicated as therapies for hereditary hemorrhagic
telangiectasia.• We interrogated the response to four antiangiogenic drugs for anemia and
intestinal bleeding.• Sorafenib and a pazopanib analog significantly improved while erlotinib
worsened anemia.• Some oral antiangiogenic drugs were effective in reducing intestinal
bleeding. Summary: Background Epistaxis and gastrointestinal (GI) tract hemorrhages are
common symptoms of aged hereditary hemorrhagic telangiectasia (HHT) patients that result …