Overexpression of Mps1 in colon cancer cells attenuates the spindle assembly checkpoint and increases aneuploidy
Y Ling, X Zhang, Y Bai, P Li, C Wei, T Song… - Biochemical and …, 2014 - Elsevier
Y Ling, X Zhang, Y Bai, P Li, C Wei, T Song, Z Zheng, K Guan, Y Zhang, B Zhang, X Liu…
Biochemical and biophysical research communications, 2014•ElsevierThe spindle assembly checkpoint kinase Mps1 is highly expressed in several types of
cancers, but its cellular involvement in tumorigenesis is less defined. Herein, we confirm that
Mps1 is overexpressed in colon cancer tissues. Further, we find that forced expression of
Mps1 in the colon cancer cell line SW480 enables cells to become resistant to both Mps1
inhibition-induced checkpoint depletion and cell death. Overexpression of Mps1 also
increases genome instability in tumor cells owing to a weakened spindle assembly …
cancers, but its cellular involvement in tumorigenesis is less defined. Herein, we confirm that
Mps1 is overexpressed in colon cancer tissues. Further, we find that forced expression of
Mps1 in the colon cancer cell line SW480 enables cells to become resistant to both Mps1
inhibition-induced checkpoint depletion and cell death. Overexpression of Mps1 also
increases genome instability in tumor cells owing to a weakened spindle assembly …
Abstract
The spindle assembly checkpoint kinase Mps1 is highly expressed in several types of cancers, but its cellular involvement in tumorigenesis is less defined. Herein, we confirm that Mps1 is overexpressed in colon cancer tissues. Further, we find that forced expression of Mps1 in the colon cancer cell line SW480 enables cells to become resistant to both Mps1 inhibition-induced checkpoint depletion and cell death. Overexpression of Mps1 also increases genome instability in tumor cells owing to a weakened spindle assembly checkpoint. Collectively, our findings suggest that high levels of Mps1 contribute to tumorigenesis by attenuating the spindle assembly checkpoint.
Elsevier