The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice
N Debeuf, A Zhakupova, R Steiner… - Journal of Allergy and …, 2019 - Elsevier
Background Genome-wide association studies in asthma have repeatedly identified single
nucleotide polymorphisms in the ORM (yeast)–like protein isoform 3 (ORMDL3) gene across
different populations. Although the ORM homologues in yeast are well-known inhibitors of
sphingolipid synthesis, it is still unclear whether and how mammalian ORMDL3 regulates
sphingolipid metabolism and whether altered sphingolipid synthesis would be causally
related to asthma risk. Objective We sought to examine the in vivo role of ORMDL3 in …
nucleotide polymorphisms in the ORM (yeast)–like protein isoform 3 (ORMDL3) gene across
different populations. Although the ORM homologues in yeast are well-known inhibitors of
sphingolipid synthesis, it is still unclear whether and how mammalian ORMDL3 regulates
sphingolipid metabolism and whether altered sphingolipid synthesis would be causally
related to asthma risk. Objective We sought to examine the in vivo role of ORMDL3 in …
