Strain specific fear behaviour and glucocorticoid response to aversive events: modelling PTSD in mice
V Brinks, ER De Kloet, MS Oitzl - Progress in brain research, 2007 - Elsevier
Abstract “Pavlovian” fear conditioning in rodents allows studying the formation and extinction
of fear memories. Male C57BL/6J but not BALB/c mice showed differential fear memory
performance expressed as freezing and scanning behaviour for context and cue.
Glucocorticoid stress hormones modulate the processing of fear-related stimuli. The
augmented corticosterone response of BALB/c mice to conditioning and testing, therefore,
might have contributed to the strain-dependent formation of fear memories. We propose that …
of fear memories. Male C57BL/6J but not BALB/c mice showed differential fear memory
performance expressed as freezing and scanning behaviour for context and cue.
Glucocorticoid stress hormones modulate the processing of fear-related stimuli. The
augmented corticosterone response of BALB/c mice to conditioning and testing, therefore,
might have contributed to the strain-dependent formation of fear memories. We propose that …