PURPOSE: HSP27 or HSP25 negatively regulates apoptosis pathways after radiation or
chemotherapeutic agents. Abrogation of HSP27 function may be a candidate target for
overcoming radio-and chemoresistance. METHODS AND MATERIALS: Zerumbone (ZER), a
cytotoxic component isolated from Zingiber zerumbet smith. Clonogenic survival assay and
flow cytometry after Annexin V staining were performed to determine in vitro sensitization
effects of ZER with ionizing radiation. A nude mouse xenografting system was also applied …