[HTML][HTML] Heat shock response modulators as therapeutic tools for diseases of protein conformation
SD Westerheide, RI Morimoto - Journal of Biological Chemistry, 2005 - ASBMB
The disruption of protein folding quality control results in the accumulation of a non-native
protein species that can form oligomers, aggregates, and inclusions indicative of
neurodegenerative disease. Likewise for over 100 other human diseases of protein
confirmation, a common feature may be the formation of off-pathway folding intermediates
that are unstable, self-associate, and with time lead to a chronic imbalance in protein
homeostasis with deleterious consequences on cellular function. This has led to a …
protein species that can form oligomers, aggregates, and inclusions indicative of
neurodegenerative disease. Likewise for over 100 other human diseases of protein
confirmation, a common feature may be the formation of off-pathway folding intermediates
that are unstable, self-associate, and with time lead to a chronic imbalance in protein
homeostasis with deleterious consequences on cellular function. This has led to a …