To recognise and respond to pathogens, germ-line encoded pattern recognition receptors
(PRRs) bind to conserved microbial structures and activate host defence systems, including
microbial uptake by phagocytosis. Phagocytosis is a complex process that is instrumental in
the control of extracellular pathogens, and this activity is mediated by several PRRs,
including a number of C-type lectins. While some of these receptors have clearly been
shown to mediate or regulate the uptake of pathogens, others are more contentious and are …