[HTML][HTML] Macrophages in collateral arteriogenesis

E Fung, A Helisch - Frontiers in physiology, 2012 - frontiersin.org
E Fung, A Helisch
Frontiers in physiology, 2012frontiersin.org
Arteriosclerotic vascular disease is the most common cause of death and a major cause of
disability in the developed world. Adverse outcomes of arteriosclerotic vascular disease are
related to consequences of tissue ischemia and necrosis affecting the heart, brain, limbs,
and other organs. Collateral artery growth or arteriogenesis occurs naturally and can help
restore perfusion to ischemic tissues. Understanding the mechanisms of collateral artery
growth may provide therapeutic options for patients with ischemic vascular disease. In this …
Arteriosclerotic vascular disease is the most common cause of death and a major cause of disability in the developed world. Adverse outcomes of arteriosclerotic vascular disease are related to consequences of tissue ischemia and necrosis affecting the heart, brain, limbs, and other organs. Collateral artery growth or arteriogenesis occurs naturally and can help restore perfusion to ischemic tissues. Understanding the mechanisms of collateral artery growth may provide therapeutic options for patients with ischemic vascular disease. In this review, we examine the evidence for a role of monocytes and macrophages in collateral arteriogenesis.
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