The retinal pigment epithelium (RPE) constitutes a monolayer of cuboidal cells that interact
apically with the interphotoreceptor matrix (IPM) and outer segments of the photoreceptor
cells and basally with the subjacent Bruch's membrane. This highly polarized structure is
maintained by the cytoskeleton of individual cells and their interactions at the basolateral
junctional complexes that stabilize this epithelial structure. This RPE complex network of
filaments, tubules and associated proteins is modeled by the cellular environment, the RPE …