[PDF][PDF] Neural subtype specification from human pluripotent stem cells

Y Tao, SC Zhang - Cell stem cell, 2016 - cell.com
Y Tao, SC Zhang
Cell stem cell, 2016cell.com
Human pluripotent stem cells (hPSCs) provide a model to study early neural development,
model pathological processes, and develop therapeutics. The generation of functionally
specialized neural subtypes from hPSCs relies on fundamental developmental principles
learned from animal studies. Manipulation of these principles enables production of highly
enriched neural types with functional attributes that resemble those in the brain. Further
development to promote faster maturation or aging as well as circuit integration will help …
Human pluripotent stem cells (hPSCs) provide a model to study early neural development, model pathological processes, and develop therapeutics. The generation of functionally specialized neural subtypes from hPSCs relies on fundamental developmental principles learned from animal studies. Manipulation of these principles enables production of highly enriched neural types with functional attributes that resemble those in the brain. Further development to promote faster maturation or aging as well as circuit integration will help realize the potential of hPSC-derived neural cells in disease modeling and cell therapy.
cell.com