Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion

A Lluis, M Schedel, J Liu, S Illi, M Depner… - Journal of allergy and …, 2011 - Elsevier
Background In a genome-wide association study, genetic variants on chromosome 17q21
were strongly associated with childhood asthma and orosomucoid 1–like 3 (ORMDL3) gene
expression. Regulation of the 17q21 locus and its immunologic relevance early in life have
not been well characterized. Objective We investigated the relation between polymorphisms
and mRNA expression of 17q21 locus genes and their influence on T-cell subsets in cord
blood. Methods In 200 children of our cord blood study, 17q21 polymorphisms were …