Aberrant ORM (yeast)–like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice
C Oyeniran, JL Sturgill, NC Hait, WC Huang… - Journal of Allergy and …, 2015 - Elsevier
Background Asthma, a chronic inflammatory condition defined by episodic shortness of
breath with expiratory wheezing and cough, is a serious health concern affecting more than
250 million persons. Genome-wide association studies have identified ORM (yeast)–like
protein isoform 3 (ORMDL3) as a gene associated with susceptibility to asthma. Although its
yeast ortholog is a negative regulator of de novo ceramide biosynthesis, how ORMDL3
contributes to asthma pathogenesis is not known. Objectives We sought to decipher the …
breath with expiratory wheezing and cough, is a serious health concern affecting more than
250 million persons. Genome-wide association studies have identified ORM (yeast)–like
protein isoform 3 (ORMDL3) as a gene associated with susceptibility to asthma. Although its
yeast ortholog is a negative regulator of de novo ceramide biosynthesis, how ORMDL3
contributes to asthma pathogenesis is not known. Objectives We sought to decipher the …