Distinct serum sphingolipid profiles among school-aged children with exercise-induced wheeze and asthma persistence

MS Perzanowski, JG Ono, LM Acosta… - American Journal of …, 2017 - atsjournals.org
MS Perzanowski, JG Ono, LM Acosta, BI Kim, A Divjan, R Miller, A Rundle, S Worgall…
American Journal of Respiratory and Critical Care Medicine, 2017atsjournals.org
Alterations in sphingolipids have been associated with chronic lung diseases (1). A role for
altered sphingolipid metabolism in asthma pathogenesis is suggested by single-nucleotide
polymorphisms in the most replicated gene locus associated with childhood asthma, 17q21,
which includes the gene for ORM-like protein isoform 3, a regulator of sphingolipid synthesis
(2). Also, decreased sphingolipid synthesis is associated with airway hyperreactivity (3).
Childhood asthma includes multiple disease phenotypes, the disentangling of which would …
Alterations in sphingolipids have been associated with chronic lung diseases (1). A role for altered sphingolipid metabolism in asthma pathogenesis is suggested by single-nucleotide polymorphisms in the most replicated gene locus associated with childhood asthma, 17q21, which includes the gene for ORM-like protein isoform 3, a regulator of sphingolipid synthesis (2). Also, decreased sphingolipid synthesis is associated with airway hyperreactivity (3).
Childhood asthma includes multiple disease phenotypes, the disentangling of which would lead to better understanding of the underlying etiologies and potential treatments. Exercise-induced wheezing (EIW) in school-aged children has been identified as an asthma phenotype that includes both atopic and nonatopic asthma (4). Because many school-aged children with asthma will not continue to have asthma symptoms, identifying risk factors that predict persistence of wheezing has been challenging.
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