Evolution of acquired resistance to anti-cancer therapy

J Foo, F Michor - Journal of theoretical biology, 2014 - Elsevier
Acquired drug resistance is a major limitation for the successful treatment of cancer.
Resistance can emerge due to a variety of reasons including host environmental factors as
well as genetic or epigenetic alterations in the cancer cells. Evolutionary theory has
contributed to the understanding of the dynamics of resistance mutations in a cancer cell
population, the risk of resistance pre-existing before the initiation of therapy, the composition
of drug cocktails necessary to prevent the emergence of resistance, and optimum drug …