Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates

JG Scammell, WB Denny, DL Valentine… - General and comparative …, 2001 - Elsevier
Many New World primates have high circulating levels of cortisol to compensate for the
expression of glucocorticoid receptors (GRs) with low activity. Recent work in squirrel
monkeys has suggested that this may be due to either the expression of GRs that are
transcriptionally incompetent or the expression of an FK506-binding immunophilin that
inhibits GR binding. The goal of this study was to resolve this controversy by determining the
molecular basis of glucocorticoid resistance not only in species of squirrel monkeys but also …