Interferon regulatory factor-1 is required for interferon-γ-induced MHC class I genes in astrocytes
KW Jarosinski, PT Massa - Journal of neuroimmunology, 2002 - Elsevier
Recent studies have shown that the role of the transcription factor interferon regulatory factor-
1 (IRF-1) in the expression of major histocompatibility complex (MHC) class I molecules is
tissue-specific. Our previous studies indicated a role for IRF-1 in expression of MHC class I
genes in cultured astrocytes in response to interferon-γ (IFN-γ). However, the requirement
for IRF-1 in MHC class I expression has not been directly analyzed in neural tissue. To
further ascertain the importance of IRF-1 in the induction of MHC class I genes in astrocytes …
1 (IRF-1) in the expression of major histocompatibility complex (MHC) class I molecules is
tissue-specific. Our previous studies indicated a role for IRF-1 in expression of MHC class I
genes in cultured astrocytes in response to interferon-γ (IFN-γ). However, the requirement
for IRF-1 in MHC class I expression has not been directly analyzed in neural tissue. To
further ascertain the importance of IRF-1 in the induction of MHC class I genes in astrocytes …