[HTML][HTML] Pneumococcal IgA1 protease subverts specific protection by human IgA1
EN Janoff, JB Rubins, C Fasching, D Charboneau… - Mucosal …, 2014 - Elsevier
Abstract Bacterial immunoglobulin A1 (IgA1) proteases may sabotage the protective effects
of IgA. In vitro, both exogenous and endogenously produced IgA1 protease inhibited
phagocytic killing of Streptococcus pneumoniae by capsule-specific IgA1 human
monoclonal antibodies (hMAbs) but not IgA2. These IgA1 proteases cleaved and reduced
binding of the the effector Fcα1 heavy chain but not the antigen-binding F (ab)/light chain to
pneumococcal surfaces. In vivo, IgA1 protease-resistant IgA2, but not IgA1 protease …
of IgA. In vitro, both exogenous and endogenously produced IgA1 protease inhibited
phagocytic killing of Streptococcus pneumoniae by capsule-specific IgA1 human
monoclonal antibodies (hMAbs) but not IgA2. These IgA1 proteases cleaved and reduced
binding of the the effector Fcα1 heavy chain but not the antigen-binding F (ab)/light chain to
pneumococcal surfaces. In vivo, IgA1 protease-resistant IgA2, but not IgA1 protease …