[HTML][HTML] Off-the-shelf virus-specific T cells to treat BK virus, human herpesvirus 6, cytomegalovirus, Epstein-Barr virus, and adenovirus infections after allogeneic …

I Tzannou, A Papadopoulou, S Naik… - Journal of Clinical …, 2017 - ncbi.nlm.nih.gov
I Tzannou, A Papadopoulou, S Naik, K Leung, CA Martinez, CA Ramos, G Carrum, G Sasa…
Journal of Clinical Oncology, 2017ncbi.nlm.nih.gov
Purpose Improvement of cure rates for patients treated with allogeneic hematopoietic stem-
cell transplantation (HSCT) will require efforts to decrease treatment-related mortality from
severe viral infections. Adoptively transferred virus-specific T cells (VSTs) generated from
eligible, third-party donors could provide broad antiviral protection to recipients of HSCT as
an immediately available off-the-shelf product.
Abstract
Purpose
Improvement of cure rates for patients treated with allogeneic hematopoietic stem-cell transplantation (HSCT) will require efforts to decrease treatment-related mortality from severe viral infections. Adoptively transferred virus-specific T cells (VSTs) generated from eligible, third-party donors could provide broad antiviral protection to recipients of HSCT as an immediately available off-the-shelf product.
ncbi.nlm.nih.gov