Adoptive immunotherapy for primary immunodeficiency disorders with virus-specific T lymphocytes
S Naik, SK Nicholas, CA Martinez, AM Leen… - Journal of Allergy and …, 2016 - Elsevier
Background Viral infections are a leading fatal complication for patients with primary
immunodeficiencies (PIDs) who require hematopoietic stem cell transplantation (HSCT).
Use of virus-specific T lymphocytes (VSTs) has been successful for the treatment and
prevention of viral infections after HSCT for malignant and nonmalignant conditions. Here
we describe the clinical use of VSTs in patients with PIDs at 4 centers. Objective We sought
to evaluate the safety and efficacy of VSTs for treatment of viral infections in patients with …
immunodeficiencies (PIDs) who require hematopoietic stem cell transplantation (HSCT).
Use of virus-specific T lymphocytes (VSTs) has been successful for the treatment and
prevention of viral infections after HSCT for malignant and nonmalignant conditions. Here
we describe the clinical use of VSTs in patients with PIDs at 4 centers. Objective We sought
to evaluate the safety and efficacy of VSTs for treatment of viral infections in patients with …