Axonal loss in multiple sclerosis: causes and mechanisms
G Criste, B Trapp, R Dutta - Handbook of clinical neurology, 2014 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system and the leading cause of non-traumatic neurologic disability in young adults
in the United States and Europe. The disease course is variable and starts with reversible
episodes of neurologic disability which transforms into continuous and irreversible
neurologic decline. It is well established that loss of axons and neurons is the major cause of
the progressive neurologic decline that most MS patients endure. Current hypotheses …
nervous system and the leading cause of non-traumatic neurologic disability in young adults
in the United States and Europe. The disease course is variable and starts with reversible
episodes of neurologic disability which transforms into continuous and irreversible
neurologic decline. It is well established that loss of axons and neurons is the major cause of
the progressive neurologic decline that most MS patients endure. Current hypotheses …